au sommaire


    Remerciements

    La partie expérimentale de cette note puise dans les travaux réalisés dans notre laboratoire et en particulier dans les expériences effectuées en collaboration avec le Professeur Tamas Fulöp, Mme Marie-Paule JacoB, M. Jean-Michel TIXIER, Mme Gabriella Peterszegi et Mlle Sophie Texier.

    La randonnée un bon exercice anti-vieillessement. © Brazzy - Domaine public

    La randonnée un bon exercice anti-vieillessement. © Brazzy - Domaine public

    Bibliographie

    1. Allard M., A la recherche du secret des centenaires. Le Cherche Midi éditeur, Paris, 1991.

    2. Archilla-Marcos M. & Robert L., Control of the biosynthesis and excrétion of the clastase-type protease of human skin fibroblastefibroblaste by the elastin receptor. Clin. Physiol. Biochem., 1993, 10, 86-91.

    3. Beregi E., Centenarians in hungary, Karger, Basel, 1990.

    4. Berr C., Facteurs de risqueFacteurs de risque des démencesdémences séniles. La revue du praticien, 1995, 9, 1 1.

    5 . Bizbiz L., Alperovitch A., Robert L. & The EVA group, Aging of the vascular scrum concentration of elastin peptidespeptides and clastase inhibitors in relation with cardiovascular risk factor. The EVA study. Atherosclerosis, 1997, 131, 73-78.

    6. Bizbiz L., Bonithon-Kopp C., Ducimetière P., Berr C., Alperovitch A., Robert L. & EVA Group, Relation of serum elastase activity to ultrasonographically assessed carotid artery wafi lesions and cardiovascular risk factors. The EVA study. Atheroscierosis, 1996, 120, 47-55.

    7 . Changeux J. P., L'homme neuronal, Fayard, Paris, 1983.

    8 . Chaudière J., Some chemical and biochemical constraints of oxidative stressstress in living cells. In: Rice-Evans C., Burdon R. H. (eds), Free radical damage and its control, Elsevier, Amsterdam, 1994, pp. 25-66.

    9. Cioce V., Castronovo V., Shmookler B. M., Garbisa S., Grigorirm W. F., Liotta L. A. & Sobel M. E., Increased expression of the laminin receptor in human colon cancercancer. J. Nati. Cancer Inst., 1991, 83, 29-36.

    10. Damasio A. R., L'erreur de Descartes, Éditions Odile Jacob, Paris, 1994. Il. Deguine V., Labat-Robert J., Ferrari P., Pouliquen Y., Menasche M. & Robert L., Vieillissement du vitré oculaire. Rôle de la glycation et des radicaux libresradicaux libres. Path. Biol., 1997, 45, 321-330.

    12. raury G., Ristori M. T., Verdetti J., Jacob M. P. & Robert L., Effect of elastin peptides on vascular tone. J. Vasc. Res., 1995, 32, 112-119.

    13. Faury G., Chabaud A., Ristori M. T., Robert L. & Verdetti J., Effect of age on the vasodilatory action of elastin peptides. Mechanisms of Ageing and Development, 1997, 95, 31-42.

    14. Fulop T. Jr, Jacob M. P.,Varga Z., Foris G., Leovey A. & Robert L., Effect of elastin peptides on human monocytesmonocytes: Ca" mobilization, stimulationstimulation of respiratory burstburst and enzyme secretion. Biochem. Biophys. Res. Commun., 1986, 141, 92-98.

    15. Hayflick L., How and why we age, Ballantine Books, New York, 1994.

    16. Hinck H., Rabinovitch M., Keeley F., Okamura-Oho Y. & Callahan J., The 67 kD clastin/laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of 3-galactosidase. J. Clin. Invest., 1993, 91, 1198-1205. Jacotot B., AthéroscléroseAthérosclérose, Sandoz, Paris, 1993. Jacocot 13., ArtèresArtères normales et athéroscléreuses. In: Athérosciéo, Sandoz, Paris, 1991, pp. 7-25. Jia Jin Y., Kettritz R., Falk R. J., Jenette C. J. & Gaido M. L. Apoptosis of endo-thelial cells induced by the neutrophil serine proteases: proteinase 3 and elastase. AM. J. Pathol., 1996, 149, 1617-1626. Kirkwood T. 13. L. & Rosenberger R. F., Accuracy in molecular processes Chapman and Hall, London, 1986.

    21. Macieira-Coelho A., Molecular bases of aging, CRCCRC Press, Boca Raton, 1995.

    22. Martin G. M., Austad S. N. & Johnson T. E., Genctic analysis of ageing: role of oxidative damage and environmental stresses. Nature Genetics, 1996, 23, 25.

    23. Peterszegi G., Robert A. M. & Robert L., Presence of the elastin-laminin receptor on human activated lymphocyteslymphocytes. C. R. Acad. Sci., 1996, 319, 799-803.

    24. Rasoamanantena P., Labat-Robert J. & Goldstein S., Variations de la biosynthèse et quantificationquantification de l'ARNmARNm de la fibronectine humaine au cours du vieillissement en culture. C. R. SocSoc. Biol., 1993, 187, 238-246.

    25. Robert L., Les horloges biologiqueshorloges biologiques, Flammarion, Paris, 1989.

    26. Robert L., Le vieillissement. De l'homme à la cellule, Belin, Paris, 1994.

    27. Robert L., Jacob M. P., Fülap T. Jr, Timar J. & Hornebeck W., Elastonectin and the elastin receptor. PathoL Biol., 1989, 37, 736-741.

    28. Robert L., Aging of vascular waH and atherogenesis. Role of the clastin-laminin receptor. Atherosclerosis, 1996, 123, 169-179.

    29. Robert L., Le vieillissement vasculaire. Rôle du récepteur de l'élastineélastine. C. R. Soc. Biol., 1995, 189, 959-966.

    30. Robert L., Le vieillissement. Faits et théories, Dominos, Flammarion, Paris, 1993.

    31. Sohal R. S. & Orr W. C., Is oxidative stress a causal factor in aging? In: K. Esser,G. M. Martin (eds), Molecular aspects of aging, John Wiley & Sons, Chichester, 1995, pp. 109-127.

    32. Svanborg A., Health and vitality, Medicinska Forskningsradet, 1988.

    33. Texier S., Peterszegi G. & Robert L., Cell death by overload of the elastin-laminin receptor on human lymphocytes, J. ImmunoL Methods, 1997, soumis.

    34. Timar J., Diczhazi C. S., Ladanyi A., Raso E., Hornebeck W., Robert L. & Lapis K.,

    Interaction of tumour cells with elastin and the metastatic phénotypephénotype. In.- The molecular biology and pathology of elastic tissues, John Wiley & Sons, Chichester, 1995, pp. 321-337.

    35. Varga Z., Kovacs E. M., Paragh G., Jacob M. P., Robert L. & Fülôp T. Jr, Effect

    of elastin peptides and N-formyl-methionyl-leucyl phenywanine on cytosolic frce calcium in polymorphonuclear leukocytes of healthy middle-aged and clderly subjects. Clin. Biochem., 1988, 21, 127-130.

    36. Varga Z., Jacob M. P., Robert L. & Fulop T. Jr, Identification and signal trans-

    ductionduction mechanism of clastin peptide receptor in human leukocytes. FEBS Letters, 1989, 2S8, 5-8.

    37. Varga Z., Jacob M. P., Csongor J., Robert L., Leovey A. & Fulop T. Jr, Altered