Rapport entre les mécanismes génétiques et épigénétiques du vieillissement - 16/06/2002

Remerciements

La partie expérimentale de cette note puise dans les travaux réalisés dans notre laboratoire et en particulier dans les expériences effectuées en collaboration avec le Professeur Tamas Fulöp, Mme Marie-Paule JacoB, M. Jean-Michel TIXIER, Mme Gabriella Peterszegi et Mlle Sophie Texier.

Bibliographie

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2. Archilla-Marcos M. & Robert L., Control of the biosynthesis and excrétion of the clastase-type protease of human skin fibroblaste by the elastin receptor. Clin. Physiol. Biochem., 1993, 10, 86-91.

3. Beregi E., Centenarians in hungary, Karger, Basel, 1990.

4. Berr C., Facteurs de risque des démences séniles. La revue du praticien, 1995, 9, 1 1.

5 . Bizbiz L., Alperovitch A., Robert L. & The EVA group, Aging of the vascular scrum concentration of elastin peptides and clastase inhibitors in relation with cardiovascular risk factor. The EVA study. Atherosclerosis, 1997, 131, 73-78.

6. Bizbiz L., Bonithon-Kopp C., Ducimetière P., Berr C., Alperovitch A., Robert L. & EVA Group, Relation of serum elastase activity to ultrasonographically assessed carotid artery wafi lesions and cardiovascular risk factors. The EVA study. Atheroscierosis, 1996, 120, 47-55.

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8 . Chaudière J., Some chemical and biochemical constraints of oxidative stress in living cells. In: Rice-Evans C., Burdon R. H. (eds), Free radical damage and its control, Elsevier, Amsterdam, 1994, pp. 25-66.

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10. Damasio A. R., L'erreur de Descartes, Éditions Odile Jacob, Paris, 1994. Il. Deguine V., Labat-Robert J., Ferrari P., Pouliquen Y., Menasche M. & Robert L., Vieillissement du vitré oculaire. Rôle de la glycation et des radicaux libres. Path. Biol., 1997, 45, 321-330.

12. raury G., Ristori M. T., Verdetti J., Jacob M. P. & Robert L., Effect of elastin peptides on vascular tone. J. Vasc. Res., 1995, 32, 112-119.

13. Faury G., Chabaud A., Ristori M. T., Robert L. & Verdetti J., Effect of age on the vasodilatory action of elastin peptides. Mechanisms of Ageing and Development, 1997, 95, 31-42.

14. Fulop T. Jr, Jacob M. P.,Varga Z., Foris G., Leovey A. & Robert L., Effect of elastin peptides on human monocytes: Ca" mobilization, stimulation of respiratory burst and enzyme secretion. Biochem. Biophys. Res. Commun., 1986, 141, 92-98.

15. Hayflick L., How and why we age, Ballantine Books, New York, 1994.

16. Hinck H., Rabinovitch M., Keeley F., Okamura-Oho Y. & Callahan J., The 67 kD clastin/laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of 3-galactosidase. J. Clin. Invest., 1993, 91, 1198-1205. Jacotot B., Athérosclérose, Sandoz, Paris, 1993. Jacocot 13., Artères normales et athéroscléreuses. In: Athérosciéo, Sandoz, Paris, 1991, pp. 7-25. Jia Jin Y., Kettritz R., Falk R. J., Jenette C. J. & Gaido M. L. Apoptosis of endo-thelial cells induced by the neutrophil serine proteases: proteinase 3 and elastase. AM. J. Pathol., 1996, 149, 1617-1626. Kirkwood T. 13. L. & Rosenberger R. F., Accuracy in molecular processes Chapman and Hall, London, 1986.

21. Macieira-Coelho A., Molecular bases of aging, CRC Press, Boca Raton, 1995.

22. Martin G. M., Austad S. N. & Johnson T. E., Genctic analysis of ageing: role of oxidative damage and environmental stresses. Nature Genetics, 1996, 23, 25.

23. Peterszegi G., Robert A. M. & Robert L., Presence of the elastin-laminin receptor on human activated lymphocytes. C. R. Acad. Sci., 1996, 319, 799-803.

24. Rasoamanantena P., Labat-Robert J. & Goldstein S., Variations de la biosynthèse et quantification de l'ARNm de la fibronectine humaine au cours du vieillissement en culture. C. R. Soc. Biol., 1993, 187, 238-246.

25. Robert L., Les horloges biologiques, Flammarion, Paris, 1989.

26. Robert L., Le vieillissement. De l'homme à la cellule, Belin, Paris, 1994.

27. Robert L., Jacob M. P., Fülap T. Jr, Timar J. & Hornebeck W., Elastonectin and the elastin receptor. PathoL Biol., 1989, 37, 736-741.

28. Robert L., Aging of vascular waH and atherogenesis. Role of the clastin-laminin receptor. Atherosclerosis, 1996, 123, 169-179.

29. Robert L., Le vieillissement vasculaire. Rôle du récepteur de l'élastine. C. R. Soc. Biol., 1995, 189, 959-966.

30. Robert L., Le vieillissement. Faits et théories, Dominos, Flammarion, Paris, 1993.

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33. Texier S., Peterszegi G. & Robert L., Cell death by overload of the elastin-laminin receptor on human lymphocytes, J. ImmunoL Methods, 1997, soumis.

34. Timar J., Diczhazi C. S., Ladanyi A., Raso E., Hornebeck W., Robert L. & Lapis K.,

Interaction of tumour cells with elastin and the metastatic phénotype. In.- The molecular biology and pathology of elastic tissues, John Wiley & Sons, Chichester, 1995, pp. 321-337.

35. Varga Z., Kovacs E. M., Paragh G., Jacob M. P., Robert L. & Fülôp T. Jr, Effect

of elastin peptides and N-formyl-methionyl-leucyl phenywanine on cytosolic frce calcium in polymorphonuclear leukocytes of healthy middle-aged and clderly subjects. Clin. Biochem., 1988, 21, 127-130.

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duction mechanism of clastin peptide receptor in human leukocytes. FEBS Letters, 1989, 2S8, 5-8.

37. Varga Z., Jacob M. P., Csongor J., Robert L., Leovey A. & Fulop T. Jr, Altered